PEO Chain Density and Uremic Toxin Adsorption
2026-08-13
The reference study shows that end-tethered methoxy-PEO films do not interact uniformly with retained uremic solutes: molecular structure, rather than solution abundance alone, strongly influences adsorption. Its surface-characterization and LC–MS workflow provides a useful framework for evaluating low-fouling biomaterials under kidney-disease-relevant chemical conditions.
Ferroptosis lncRNA Signature in Pancreatic Cancer
2026-08-12
This study developed and externally validated a nine-lncRNA ferroptosis-related signature for estimating overall survival and immune-treatment patterns in pancreatic adenocarcinoma. Its main contribution is a reproducible computational framework that connects ferroptosis-associated transcriptional regulation with risk stratification, while also highlighting the need for prospective and functional validation.
FAISL, Calpain-2, and FAK Stability in TNBC
2026-08-12
The reference study identifies FAISL as a focal adhesion kinase (FAK)-interacting long non-coding RNA that stabilizes FAK by preventing calpain-2-mediated proteolysis. Its combination of TCGA analysis, RNA immunoprecipitation sequencing, mechanistic cell experiments, and nanoparticle-delivered siRNA links RNA-dependent control of protein turnover to triple-negative breast cancer progression and metastasis.
UK-5099 in Whole-Blood Immunometabolism
2026-08-11
UK-5099, also called PF-1005023, provides a practical way to test how mitochondrial pyruvate entry shapes cytokine responses, cellular energy status, and glucose handling. This guide translates a standardized whole-blood stimulation framework into an adaptable workflow with dose selection, controls, orthogonal readouts, and troubleshooting guidance.
Bufalin–CRISPR Nanomedicine for Colorectal Cancer
2026-08-10
The reference study develops calcium lactate nanoparticles that co-deliver bufalin and CRISPR/Cas9 ribonucleoproteins targeting CD47 to combine cancer-cell killing with immune-microenvironment remodeling. Its multimodal design links pyroptosis, apoptosis, macrophage M1 repolarization, and enhanced phagocytosis, providing a mechanistic framework for local tumor control and systemic antitumor immunity.
T0070907: A Translational Lens on PPARγ
2026-08-09
T0070907 provides a precise way to interrogate PPARγ-dependent transcription, RXRα/PPARγ pathway activity, adipogenesis, and cancer-cell cycle regulation while helping translational researchers distinguish pathway causality from downstream association.
Oligo (dT) 25 Beads for Multiomics RNA Design
2026-08-08
Oligo (dT) 25 Beads enable selective eukaryotic mRNA isolation through polyA tail capture. This guide connects bead-based purification to defensible RNA-seq and metabolomics study design, using goose muscle multiomics as a practical case study.
NMDA: Practical Excitotoxicity Assay Workflows
2026-08-07
Build reproducible excitotoxicity, calcium influx, and oxidative stress experiments with NMDA while preserving a clear link between receptor activation and downstream cell-death phenotypes. A practical workflow also shows how the NMDA glaucoma model can be paired with BMP4-GPX4 readouts to study retinal ganglion cell injury and protection.
Rottlerin: Strategic Utility of a PKC Inhibitor in Translati
2026-08-07
This article offers a thought-leadership perspective on Rottlerin, a selective PKC inhibitor, bridging mechanistic insight with practical strategy for translational researchers. By integrating rigorous evidence and workflow guidance, we highlight how Rottlerin (SKU B6803, APExBIO) serves as a precision tool for dissecting cell proliferation, apoptosis, and endothelial barrier function—key factors in oncology and beyond.
Tetrandrine Alkaloid: Strategic Ion Channel Modulation in Tr
2026-08-06
Explore the mechanistic depth and translational potential of Tetrandrine alkaloid as a DMSO-soluble, high-purity tool for ion channel modulation, inflammation, and cancer biology. This thought-leadership article fuses protocol insights, competitive benchmarking, and a vision for next-generation translational research.
Temozolomide: Applied Workflows in DNA Repair and Glioma Mod
2026-08-06
Temozolomide is the small-molecule alkylating agent of choice for dissecting DNA repair mechanisms and modeling chemotherapy resistance, particularly in advanced glioma research. This article delivers hands-on workflow enhancements, troubleshooting strategies, and actionable protocol parameters to maximize experimental reproducibility and interpretability.
Targeting Cdc42 to Mitigate Kidney Fibrosis: Mechanistic Ins
2026-08-05
A recent study identifies the small GTPase Cdc42 as a central mediator of kidney fibrosis and demonstrates that daphnepedunin A, a natural diterpenoid, can suppress fibrotic progression by modulating Cdc42-driven GSK-3β/β-catenin signaling. These findings provide a mechanistic rationale for selective Cdc42 inhibition as a therapeutic strategy in chronic kidney disease.
WSP-5: Advanced Probe for Live-Cell Hydrogen Sulfide Detecti
2026-08-05
WSP-5 (Washington State Probe-5) enables highly sensitive, real-time detection of hydrogen sulfide (H2S) in live cells via a fast, selective fluorogenic mechanism. This article details its mechanism, validated benchmarks, and best-practice application parameters for disease-relevant research.
Modulating Ionizable Lipids for Organ-Selective mRNA Deliver
2026-08-04
This study presents a multidimensional chemical approach to rapidly generate and optimize ionizable lipids (ILs) for lipid nanoparticle (LNP)–mediated, organ-selective mRNA delivery. The findings establish structure–function links that enable targeted mRNA transfection and have direct implications for improving the specificity and efficacy of mRNA therapeutics.
Programmable 3D Gold Nanocluster Arrays via Polymer Pen Lith
2026-08-04
This study introduces a scalable, precisely tunable approach for fabricating highly ordered three-dimensional gold nanocluster arrays using polymer pen lithography (PPL). The resulting SERS substrates achieve exceptional sensitivity and reproducibility, advancing the practical deployment of SERS in biosensing and analytical applications.
464 records 9/31 page Previous Next First page 上5页 678910 下5页 Last page